Bioactive lipids-based therapeutic approach to COVID-19 and other similar infections
نویسندگان
چکیده
It is suggested that COVID-19 (coronavirus) and other enveloped viruses can be inactivated by bioactive lipids. Bioactive lipids (BALs) AA, gamma-linolenic acid (GLA), dihomo-GLA (DGLA), eicosapentaenoic (EPA), docosahexaenoic (DHA) are precursors to anti-inflammatory metabolites prostaglandin E1, lipoxin A4, resolvins, protectins maresins enhance phagocytosis of macrophages leukocytes clear debris, microbial clearance wound healing restore homeostasis. BALs influence cell membrane fluidity thus, prevent SARS-CoV-2, influenza, Arboviruses (such as Chikungunya, Dengue, Zika) infect the target cells. modulate generation M1 M2 macrophages. Mesenchymal adipose tissue-derived stem cells secrete LXA4 bring about their beneficial actions in COVID-19. Prostaglandin E2 (PGE2), derived from arachidonic acid, triggers A4 modulates pathogenesis precursor both PGE2 LXA4, suited ameliorate
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ژورنال
عنوان ژورنال: Archives of Medical Science
سال: 2021
ISSN: ['2657-7941']
DOI: https://doi.org/10.5114/aoms/135703